Myeloidsarcoma (MS) is a tumor composed of granulocytic precursor cells occurring in an extramedullary location.MS are rare neoplasms whose knowledge is largely based on case reports. MS is often initially misdiagnosed, the most common alternative diagnoses being lymphoma, undifferentiated cancer, malignant melanoma, extramedullary hematopoiesis and inflammation. Immunohistochemistry and immunophenotying are crucial for the accurate diagnosis of MS.

COVID-19 is responsible for an actual worldwide pandemic. It has been recently incriminated in thrombotic events and coagulopathy in severe cases of COVID-19. The cytokine storm and the severe inflammatory response are the most plausible mecanisms. Upper limb venous thrombosis is not very frequent as a thrombotic complication. The authors report the case of multiple venous thrombosis in a COVID-19 patient, and its management.

In the last decades several findings have documented the strong association between sleep apnea and cardiovascular disease, above all in the arrhythmologic field. The hypoxic trigger due to repetitive nightly apnoic events may be responsible of the onset and the maintenance of the arrhythymias such as atrial fibrillation or atrial flutter. The evidence supports a close link between these two pathological entities. Even if the perspective was always directed from sleep apnea to cardiovascular disease, the physiopathological pathways that link both are not still completely know. So it is thinkable that also the cardiovascular condition might influence the respiratory trend as the first input regarding the continuous changes happening during alternance between arrhythymias and restore heart rate stability. This case report could be an opportunity of reflection in this way. Future research is expected to clarify the real link between heart and sleep in the different cardiac condition and vice versa.

Introduction: Our preliminary trial revealed the correlation between cognitive ability and active ability, blood vessel age, and stress. From this result, a method to eliminate stress and favorably influence blood vessels and activity capacity was examined. We developed a method where elderly participants danced to familiar music while executing brain training tasks. Methods: Verified method is a brain training developed from music therapy and dance. As brain training, the effectiveness of training tasks such as dual-task (performing two tasks simultaneously) and n-back task (recall task for items shown n steps earlier) have been verified. Additionally, methods developed in this study utilized "ostinato", a rendition often used in music such as folk music. This method repeats a short phrase multiple time. As it has a trait which makes it easy to retain and recall, a repeated melody which speeds up is easily retained in memory. Analysis in that is a comparison between intervention and control. Cognitive tests and stress checks were compared with a paired One-way analysis of variance. Result: Data of 102 people were analyzed. In comparison to the control group, cognitive function was improved and distress was reduced in the intervention group. Scores of cognitive test items: immediate memory and recall delayed memory were significantly improved (p < 0.05). Conclusion: The brain training dance to familiar music improved cognitive abilities. This activity can relieve stress. Following this study, we want to evolve the brain training dance that elderly in various conditions can do and increase the volume of fun activities available to the elderly

Background: HIV is commonly associated with positive antiphospholipid antibodies and lupus anticoagulant (LA) assay, but association with clinical evidence of thrombosis is not well established. To our knowledge, we are the first to describe concurrent Pulmonary Embolism (PE), ischemic stroke due to paradoxical embolism, and renal infarction occurring in the presence of Patent Foramen Ovale (PFO) and HIV-related Antiphospholipid syndrome (APS). Clinical Presentation: This article reports a 60-year-old male with pertinent past medical history of HIV presented to the ER with left-sided weakness, slurred speech and left facial droop. Patient was highly suspected of ischemic stroke and given tPA. The CT angiogram (CTA) head and neck was negative, but revealed bilateral PE, later confirmed by CTA chest. This was determined to be an unprovoked PE. CTA chest also revealed large left renal infarction, later confirmed by renal radioisotope scan. Repeated EKG showed atrial flutter, and TTE with bubble study revealed a 3 mm PFO. Hypercoagulability work-up revealed LA. Conclusion: Clinical significance of aPL antibodies, positive LA assay in HIV infection remains unclear. Yet, several casereports, including our own, describe major thrombotic events, including PE, CVA and renal infarction. We can conclude, that screening for APS in HIV patients, especially those with intracardiac shunts, followed by proper anticoagulation, may prevent life-threatening thrombotic events.

Context Pancreaticocolonic fistula is a rare and potentially critical complication of necrotizing pancreatitis. We report a complex case of multiple Pancreaticocolonic fistulas that was successfully treated with extended left hemicolectomy. Case report A forty-three-years-old male patient, presented in our emergency department with epigastric pain, vomiting, diarrhea and weight loss for 4 weeks duration, with past history of acute gall stone pancreatitis 10 weeks earlier. Contrast enhanced computed tomography abdomen showed multiple Walled-off Pancreatic Necrosis in the peripancreatic, right paracolic and left paracolic regions up to left inguinal region with extensive Pneumoretroperitoneum. The periduodenal collection caused duodenal compression. Laparotomy done for pancreatic necrosectomy, relieving the duodenal compression, and drainage of all collections. We noticed multiple Pancreaticocolonic fistulas, 5 in numbers, between the transverse and descending colon and their neighboring collections, extended left hemicolectomy done. Multiple abdominal drains had been put for continuous postoperative irrigation. The patient discharged home but after 3 months of a hectic post-operative course. Discussion To the best of our knowledge this is the first case to be reported in the literature with multiple walled-off pancreatic necrosis associated with multiple Pancreaticocolonic fistulas (5 in Number) in both transverse and descending colon. Conclusion Necrotizing pancreatitis is a devastating disease, the presence of Pneumoretroperitoneum does not essentially only point to infected necrosis, but the possibility of Pancreaticocolonic fistula should always be kept in mind and searched for the diagnosis of pancreaticocolonic fistulas.

Abstract Painting and Impressionism comes in the beautify of human creation. This affects the visual variation of elements and the way we view our social correlation. The demonstration of visual elements affects the way we view a visual composition. Painting enhances human intelligence and this affects the way we relate and correlate ideas like mind mapping. It affects how we think and the visual elements that determined the world around us. It is a constant study of the profound elements of the visual arts and neuroscience. Perhaps neuroscience is the greatest gift to support the visual elements and cognitive hierarchy. Neuroscience and the visual world around us enhance ourselves through vision. Creative prodigies are known to be able to correlate all three applications neuroscience, the visual arts, and mathematics. The brainpower that enhances the visual cognitive price of human intelligence.

Acute and chronic pancreatitis post scoliosis correction surgeries have been reported before as a rare complication. Many hypothesis were suggested including direct trauma and waves generated by the high speed drilling and re-allignment of the spine after the surgery. In all the cases reported before there was an element suggesting those hypothesis. In this case, there was no evidence that the pancreatitis is caused by the spinal surgery at all. 14-year-old girl who was admitted for elective scoliosis surgery on. She was unwell post operatively, with a rising CRP and an increasingly distended abdomen. A CT abdomen was performed and showed some free fluid but no free gas. She went for a diagnostic laparoscopy due to failure of conservative management. This showed extensive inflammation of the right side of the colon, adherent to the bowel and that led to laparotomy and extended right hemicolectomy and ileostomy formation. The surgical samples from the bowels has been sent for pathology in which showed manifestations of Pancreatitis. No cause identified for diagnosis. The histology Macroscopy report of the biopsy samples in this patient showed congested and oedematous serosa with adhesions and patchy, fibrinopurulent exudate extending along almost the entire length of the specimen (Right Hemicolectomy). Microscopically: There is extensive mesenteric panniculitis with multifocal neutrophilic abscesses surrounding fat necrosis. There was extensive saponification and necrosis. There are acute and chronic inflammatory cells within the fat necrosis -foamy histiocytes, lymphocytes, neutrophils and plasma cells.

Environmentally friendly natural dyes have been used in food, textile, medicine fields. The red cabbage (Brassica oleracea) plant including cyanidin is usually used as food material. However, due to the presence of anthocyanins, cyanidin can be evaluated as a source of dyes. The cells were examined by staining. Onion roots and human blood used to disseminate the use of plant-derived dyes and to show the staining of the nuclei of different cells. The alum also used as a mordant material for bonding between cell core and dyestuff. Furthermore, only onion roots treated with salicylaldehyde for been having cell walls and then taken to the dye solution. A few drops of blood taken from healthy, voluntary 20-years old person spread peripherally. A top of onion provided from a local market immersed in a small beaker of water and its roots put into 70% ethyl alcohol. 20% red cabbage extract prepared. 1 piece of onion root and blood preparation put into the extract. They subjected firstly at room temperature and secondly 50° C for one-hour to dyeing processes. In addtion, one of the onion root immersed in the dye solution after standing in salicylaldehyde. The other root directly added to the dye solution. Both solutions kept at 50° C for 1 hour. After staining, onion root cells and blood cells washed. They examined as × 40, × 100 magnitudes in the light microscope. No staining observed in both cell types at room temperature. When the temperature of the dye bath increased, a blue coloring observed in the nucleus of onion stem cells. Especially erythrocytes in blood cells stained dark blue with alum. No staining observed in the onion stem cells treated with salicylaldehyde. That is, the onion roots stained in the dye bath containing alum mordant without salicylaldehyde.

The temperature distribution and thickness design of the human infectious disease COVID-19 protective clothing are studied in this paper. Based on the data provided by China mathematical modeling competition in 2018. We establish the temperature distribution model and skin layer heat conduction and burn model. The interface continuous conditional difference method, differential iterative method, least squares method and the chasing method are used to solve the given temperature distribution on the the human infectious disease COVID-19 protective clothing in the environment, and analyze the human infectious disease COVID-19 protective clothing meeting the actual needs.

Insulinoma is a rare neuroendocrine tumor of the pancreas that produces insulin in an uncontrolled fashion. Due to high circulating insulin levels in the blood, patients will often, if not most times, present with neurological symptoms. Symptoms can range in severity depending on the degree of hypoglycemia. In the most severe form, patients can experience seizures and coma. In less severe cases, they can present with fatigue, confusion, weakness, change in personality. Symptoms that resolve with food intake is a traditional hallmark. This hallmark diagnostic criteria should alert the health care provider to this diagnosis when a patient presents as such.

SARS-CoV-2, the virus responsible for COVID-2019, is a new coronavirus discovered in the city of Wuhan in China in December 2019. It is responsible for an epidemic which epicenter was in China, Human-to-human transmission caused spread of the virus to Europe then to other countries, causing a pandemic. We report the first SARS-COV2 case confirmed hospitalized in intensive care in Morocco and describe the diagnostic procedure, clinical evolution and its management. This case highlights the importance of close coordination between clinicians and public health authorities at the national level.

Neoadjuvant chemotherapy is the standard of care in inoperable locally advanced breast cancer (LABC), as it helps in reducing tumor burden and facilitating surgical resection. We describe a 56-year-old post-menopausal woman who presented with a huge, right breast mass extending from the clavicle to the mid abdomen. A chest-abdomen-pelvis computed tomography showed the mass invading the pectoralis muscles and right axillary lymph node with no evidence of distant metastasis. A needle core biopsy revealed an infiltrating ductal carcinoma (Scarff-Bloom- Richardson grade 3). A multidisciplinary collaboration was undertaken, and the patient was started on docetaxel; however, after three cycles of docetaxel, she showed no improvement and was readmitted for palliative mastectomy with skin grafting. A post-operative histopathology examination of the excised tumor revealed an invasive micropapillary carcinoma. A multidisciplinary approach is the cornerstone for the treatment of LABC. In the case of chemoresistance, very few treatment options are available.

SARS-CoV-2 is a novel coronavirus responsible of the latest pandemic. It can have various manifestations starting from respiratory to neurological, abdominal. The aim of this article is to emphasize the clinical reasoning in the presence of neurological symptoms in COVID19 patients. Our case is COVID19 female that presented an episode of generalized convulsions. A panel of tests have been conducted to explore the possible aetiology of her seizure.

COVID 19 (SARS-CoV-2 infection) was declared as a pandemic by the WHO on March 11th, 2020. Its mortality risk is correlated to its pulmonary complications and refractory hypoxemia. Therefore, the association cancer and SARS-CoV-2 infection is very widespread. The authors of this article report a case of a bronchogenic carcinoma with multifocal metastasis revealed by SARS-CoV-2 infection emphasizing the difficulties of management; COVID 19 or lung cancer: what should we treat?